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AS 604850

Product Name
AS 604850
CAS No.
648449-76-7
Chemical Name
AS 604850
Synonyms
CS-538;AS 604850;AS-604850;AS 604850;AS 604850 USP/EP/BP;PI 3-Kγ Inhibitor II;AS604850; AS 604850; AS-604850;PI 3-Kinase Inhibitor (AS604850);PI 3-Kinase Inhibitor (AS604850) B-0302;PI 3-Kγ Inhibitor II AS-604850 AS604850;PI 3-Kγ Inhibitor II - CAS 648449-76-7 - Calbiochem
CBNumber
CB5972768
Molecular Formula
C11H5F2NO4S
Formula Weight
285.22
MOL File
648449-76-7.mol
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AS 604850 Property

Density 
1.71
storage temp. 
2-8°C
solubility 
DMSO: >10mg/mL
form 
solid
pka
7.07±0.20(Predicted)
color 
off-white
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Safety

Hazard Codes 
Xi
Risk Statements 
43
Safety Statements 
36/37
WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H317May cause an allergic skin reaction

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
A0231
Product name
AS 604850
Purity
≥98% (HPLC), solid
Packaging
5mg
Price
$171
Updated
2024/03/01
Sigma-Aldrich
Product number
528108
Product name
PI 3-Kγ Inhibitor II
Packaging
5mg
Price
$272
Updated
2024/03/01
Cayman Chemical
Product number
10010175
Product name
AS 604850
Purity
≥98%
Packaging
1mg
Price
$26
Updated
2024/03/01
Cayman Chemical
Product number
10010175
Product name
AS 604850
Purity
≥98%
Packaging
5mg
Price
$111
Updated
2024/03/01
Sigma-Aldrich
Product number
A0231
Product name
AS 604850
Purity
≥98% (HPLC), solid
Packaging
25mg
Price
$848
Updated
2023/06/20
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AS 604850 Chemical Properties,Usage,Production

Description

Phosphatidylinositol 3-kinase (PI3K) catalyzes the phosphorylation of PI at the three position of the inositol ring to produce the second messengers PtdIns-(3,4)-P2 and PtdIns-(3,4,5)-P3. PI3Kγ is a class 1B PI3K that is composed of a p110 catalytic subunit and a p101 or p84 regulatory subunit, whereas PI3Kα, β, and δ are class 1A enzymes composed of p110 and p85 subunits. AS-604850 is a selective, ATP-competitive inhibitor of PI3Kγ with IC50 values of 0.25, >20, >20, and 4.5 μM for the human recombinant γ, δ, β, and α isoforms, respectively. AS-604850 inhibited MCP-1-mediated monocyte chemotaxis with an IC50 value of 21 μM and reduced RANTES-induced peritoneal neutrophil recruitment in a murine model of leukocyte chemotaxis with an ED50 value of 42.4 mg/kg.

Uses

AS-604850 is a selective and ATP-competitive phosphoinositide 3-kinase gamma (PI3Kγ) inhibitor.

References

1. camps m, rückle t, ji h et al. blockade of pi3k-gamma suppresses joint inflammation and damage in mouse models of rheumatoid arthritis. nat med. 2005 sep;11(9):936-43.2. hohenester s, gates a, wimmer r et al. phosphatidylinositol-3-kinase p110γ contributes to bile salt-induced apoptosis in primary rat hepatocytes and human hepatoma cells. j hepatol. 2010 nov;53(5):918-26.

AS 604850 Preparation Products And Raw materials

Raw materials

Preparation Products

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AS 604850 Suppliers

China 87 India 1 Switzerland 1 United Kingdom 1 United States 16 Global 106
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View Lastest Price from AS 604850 manufacturers

Career Henan Chemical Co
Product
AS 604850 648449-76-7
Price
US $7.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
1000KG
Release date
2019-07-09

648449-76-7, AS 604850Related Search:

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